This digitization, i.e., the process by which analog information is converted into digital format, enhances former analog objects by becoming programmable, addressable, sensible, communicable, memorable, traceable, and associable (Yoo 2010, pp. 225).
Nucleotide-mediated phosphorolytic removal of chain-terminating 3'-terminal nucleoside inhibitors such as AZT forms the basis for HIV-1 resistance to such drugs, and this removal is enhanced by thymidine analog mutations (TAMs).
Furthermore, LCL385, a B13 analog, enhanced the sensitivity of prostate cancer cells to radiation and inhibited tumor growth in a nude mouse model.
The results showed that both noscapine and its brominated analogs enhanced ROS release in LPS primed cells when added just prior to triggering the respiratory burst, but not in unprimed macrophages (Figure 8).
The current study shows that noscapine and its brominated analogs enhanced ROS release in LPS primed human macrophage cells but not in unprimed macrophages when added just prior to triggering the respiratory burst.
Prostacyclin analogs enhanced OPC migration via a protein kinase A (PKA -dependent mechanism, and PKA -dependentynthase expression was increased in the spinal cord after LPC injection.
Dimethylation and diethylation of the amino group of the phen-NH2 ligand in (btp 2Ir phen-NH2) and its analog significantly enhanced the cellular uptake efficiency as compared with their neutral analog with an acetylacetonate (acac) ligand.
An analog with a hydrophilic tail and a disrupted pharmacophore (cyclo[EKTOVGOGN]FS) exhibited no growth inhibition activity of its own and did not affect the activity of a hydrophobic-tailed analog, but enhanced the growth inhibition activity of AFPep.
We observed that PRI-2191, as well as PRI-2205 analog, significantly enhanced the antitumor activity of 5-FU, but these results depend on the treatment regimen.
Previous studies showed that AMD3100 or its analog AMD3465 enhanced the anti-leukemic effects of chemotherapy or that of the FLT3 inhibitors and resulted in markedly reduced leukemic burden and improved overall survival.
