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Rottweilers were developed in Germany to drive cattle to market and guard the money purse on the way home and so they have enhanced aggression, said Dr. Nicholas H. Dodman, director of the animal behavior clinic at the Tufts University School of Veterinary Medicine and author of "Dogs Behaving Badly".
In a previous report, increasing the activity of octopaminergic neurons via expression of the NaChBac sodium channel enhanced aggression above a low level seen after 5 days of group-rearing of the flies [20].
She also said that just as people can breed dogs with enhanced aggression, people can and should breed pet dogs that are nonaggressive.
While agreeing that it is important to strengthen laws against aggressive dogs, people should also have to "go through hoops" to get and keep an animal known for enhanced aggression, said Dr. Andrew Rowan, senior vice president of the Humane Society of the United States.
A similar enhanced aggression level was previously found in groups of male Japanese quail subject to social instability [43], [45].
It is possible that the reason for enhanced aggression is the accumulation of DA due to an enhanced level of expression of the Th gene, which codes for TH, the key enzyme in DA synthesis.
Similar(51)
Moreover, mice with over-expression of APP and mutation of presenilin (a risk factor for familial Alzheimer's disease) have increased production of amyloid-β protein and display enhanced territorial aggression when compared to wildtypes [52].
In a crustacean model of aggression, raising or lowering 5HT levels by pharmacological means enhances aggression [54].
We discovered in male FVB/N mice that mild (∼50%) transgenic overexpression of Mecp2 enhances aggression.
The mixing of pigs in an occupied pen is likely to enhance escalated aggression from the occupants without reducing that from the intruders and should be avoided.
However, in a few tumor types (e.g., malignant peripheral nerve sheath tumors) knockdown of RHAMM levels actually enhances tumor aggression.
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