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Ampicillin showed the highest percentage of enhanced activity against both P. aeruginosa and S. flexneri, and its activity was enhanced by AgNPs.
Thus, there is an urgent need for anti-TB drugs with enhanced activity against MDR strains.
Tedizolid is a novel oxazolidinone antibacterial drug designed to provide enhanced activity against Gram-positive pathogens.
Treatment of these infections require the use of antibiotics with enhanced activity against a broad spectrum of respiratory and urinary pathogens.
Based on the applied QSAR studies were identified molecular determinant with the greatest influence on the antiproliferative activity and designed novel compounds with enhanced activity against MCF-7 breast cancer cells.
So far, it was introduction of a trifluoromethyl group to compound 6, to generate 2- 2-trifluoromethyl-benzyl -1,2,3,4-tetrahydro-isoquinoline (13) that exhibited enhanced activity against TarO.
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Compounds 81 83 with terminal hydroxyl group as side chain displayed enhanced activities against MALT1.
Compounds 7a and 7d exhibited enhanced activities against MGC-803 in vitro, when compared to 5-Fu.
The preliminary results showed that compared to thalidomide 4a and 4b exhibited enhanced activities against ECV304 and HepG2 cells, whereas 6c was more potent against HepG2 cells.
Efforts are being made to engineer enzymes with enhanced activities against haloalkanes, a toxicologically important class of compounds widely used and frequently occurring in the environment.
The best compound among them 5 shows close to four-fold enhanced activities against P. falciparum and E. coli cultures as compared to triclosan.
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