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The trial used an enhanced accelerated titration design (Simon et al, 1997; Vickers et al, 2006; Vickers, 2006; Anderson et al, 2007), specifically an open-label, two-centre, single arm, phase I trial employing a three-plus-three dose-escalation design.
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This may lead to progressive destruction of alveolar tissue and thereby enhance accelerated decline in lung function of COPD.
It has been conjectured that this is a result of reducing compliance to the radiotherapy component and possibly enhancing accelerated repopulation of resistant clones with induction chemotherapy.
KPMG Ignite, our AI technology portfolio, helps clients enhance, accelerate and automate decisions and processes with proprietary accelerators patterns and tools that allow for the rapid development and delivery of AI solutions— built atop market-leading KPMG, open source, and partner technologies.
In the laboratory, these processes can be enhanced and accelerated to evolve proteins for specific functions.
But their ability to reap benefits from these advances is enhanced and accelerated by government policy, including regulation promoting renewable energy and energy efficiency.
Thus, increasing levels of plasma homocysteine enhanced and accelerated the smooth muscle cell response after CEA which led to increased intimal hyperplasia and lumenal stenosis.
In human and murine malignant melanoma cells, metastatic dissemination is enhanced and accelerated via Snail-induced EMT [90], and bone metastases of human prostate carcinomas show significant overexpression of Notch-1 compared to the primary tumors [75].
Hur et al. [ 181] showed that Cx43 hemichannels enhanced and accelerated cell death following staurosporin treatment.
Molecule transport into microalgae intracellular compartments could be enhanced and accelerated by the establishment of an electric field [ 96].
Capacity building is essentially an internal process that can be enhanced or accelerated by outside groups [ 16, 25].
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