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The NGX-4010 application can be associated with application-site pain and in previous clinical trials pretreatment with a topical 4% lidocaine anesthetic was used to enhance tolerability.
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As compared with binary polyplex micelles of PEG-b-PAsp DET) (BPEG-b-PAsp DETe confirmed to condense PEG-b-PAsp DETre compact structure, which achieved enhanced toleraBPMsTPMso nuclease digestion and strong counter polyanion exchange.
Considering that naproxen has a notable promotion on the tolerability of sumatriptan and that diclofenac-potassium has outstanding behaviors with respect to efficacy, it is desirable to design further experiments to enhance the tolerability of diclofenac-potassium (Additional file 4: Figure S3).
Given that severe transient colitis had been induced by intravenous infusion of CEA-specific TCR-transduced T cells in a previous study (Parkhurst et al., 2011), a regional delivery strategy was adopted aiming to enhance the tolerability and therapeutic efficacy of anti-CEA CAR-T cells.
To enhance the tolerability of diclofenac and decrease the common side effects, aceclofenac (ACE) was developed by its chemical modification.
To enhance the tolerability profile of such vaccines attempts have been made to diminish the allergenicity of vaccine components while maintaining their ability to induce protective immunity.
Adults swallow the capsule with water, but to enhance the tolerability of the procedure for children we hypothesized that the use of a "sweetener" might be helpful ("la cuerda dulce" is Spanish for "the sweet string").
The development of a fixed-dose combination of diclofenac sodium and a gastroprotective agent, misoprostol, a synthetic prostaglandin, or co-administration of a diclofenac enteric-coated tablet with proton pump inhibitors provided an alternative approach to enhance GI tolerability.
ABT-199 offers a great clinical opportunity because of its specificity to BCL-2 which enhances its tolerability as well as its unique mechanism of action directly at mitochondria.
Hence, STF is a promising strategy to enhance the efficacy and tolerability of chemotherapy.
There have been several innovations to improve tolerability and enhance therapeutic effects of proteins in the body.
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