Sentence examples for enhance potency from inspiring English sources

Bi-functional design may further enhance potency and safety of RNAi-based therapeutics.

One method to enhance potency is to include a genetic adjuvant in the formulation of the DNA vaccine.

To further enhance potency and/or add functionality, design of prodrugs may also incorporate other structural elements or ancillary pharmacophores.

In addition, its selective inhibition could not only enhance potency, but also reduce the toxicities related to off-target effects of pan-HDAC inhibitors.

Substitutions adjacent to the amino group in the 2-phenyl ring with a halogen atom or methyl group enhance potency in sensitive breast lines (pM IC50 values).

Biasing the strand-selection of the guide strand, rather than of the passenger strand, can enhance potency while also reducing off-target effects of the passenger strand.

One way to enhance potencies of DNA vaccines is to increase antigen expression in professional antigen presenting cells, such as dendritic cells.

Degraders of BRD9 exhibit markedly enhanced potency compared to parental ligands (10- to 100-fold).

Based on these results, a series of carbamates was designed that display enhanced potency.

In the present study, in general, substituting hydroxamates for the amide of ROC maintains or enhances potency while conversion to ester decreases potency (e.g., compare ROC to CMLD010852).

Six compounds showed EC50 values below 35 nM, and several derivatives also exhibited significantly enhanced potency and high selectivity at the CB2 receptor over the CB1 receptor.