Sentence examples for enhance pathology from inspiring English sources

Subsequently, and supportive of this hypothesis, transthyretin protein was shown to prevent Aβ toxicity in vitro [24,25] and in mice over-expressing APP, neutralisation with antibody or deletion of the TTR gene both enhance pathology [26,27].

However, the treatment of mice with anti-Tim-3 and anti-PD-1 neutralization antibodies did significantly enhance pathologies in the upper genital tract, demonstrating that the antibody treatment was effective in blocking of Tim-3 and PD-L1 signaling pathways.

However, the mouse model did not support a role of CTLA-4 in enhancing pathology.

Our finding that CCL3 inhibition enhances pathology is similar to the finding that in a model of nephritis CCR1−/− (the main receptor for CCL3) mice have enhanced pathology associated with increased TNF levels [16].

Collectively, the observation of the role of the CTLA4 −6230 polymorphism and the occurrence of a haplotype/diplotype bearing the CTLA4A variant in pulmonary TB indicates that a reduced CTLA-4 activity in humans does not enhance protection against pulmonary TB but enhances pathology if containment of the infection fails.

C5L2 stimulation by C5a caused release from cells of the protein high mobility group box 1 (HMGbothboth in vitro and in vivo and enhanced pathology in sepsis models [ 74].

Recently, BECN1 deficiency was shown to enhance the pathology of a mouse model of Alzheimer Disease ADD).

From a mechanistic perspective, insulin resistance may enhance cardiac pathology following a MI by inhibiting changes in metabolic characteristics that are initially suggested to be adaptive [ 26- 30].

Although inflammation may not be the cause of pre-eclampsia, it may enhance the pathology of the disorder in the presence of the anti-angiogenic factors.

Inflammation may enhance the pathology induced by the imbalance in the angiogenic factors, but does not by itself cause pre-eclampsia.

Given that tau species phosphorylated on KXGS motifs are resistant to degradation and accumulate in NFTs [ 30], fail to bind and stabilize microtubules [ 36], and are also primed for phosphorylation by other kinases [ 29, 31], hyperactivation of HDAC6 would be expected to considerably enhance tau pathology.