Exact(3)
Current gaps still exist for a key gene that could effectively target neuroprotection, enhance neuron regeneration and sustain neuronal function.
Olfactory ensheathing cells (OECs) are being trialled for cell transplantation therapies for neural repair as they have unique properties which can enhance neuron regeneration.
These results indicate that rosiglitazone can augment recovery of injuries by wild-type hMSC implantation to enhance neuron differentiation.
Similar(57)
The DNA region 28 31 kb upstream of appb is likely to have additional activator sites that enhance neuron-specific expression.
When compared with the conventional poly-l-ornithine surfaces, a standard substratum commonly used for neuron culture, this new-type thin film scaffold shows enhanced neuron differentiation.
Importantly, knockdown of the EZH2 gene in ESCs markedly enhances neuron differentiation during neocortical development (Hirabayashi et al, 2009).
Previously, we showed that EZH2 downregulation enhances neuron differentiation of human mesenchymal stem cells (hMSCs); however, the underlying mechanisms of EZH2-regulated neuron differentiation are still unclear.
In our previous study, polyethylenedioxythiophenes with a cell-membrane-mimicking strategy were synthesized and showed specific neuron targeting and enhanced neuron cell adhesion and proliferation [ 20].
Therefore, PPARγ agonist treatment after hMSCs implantation may augment recovery of injuries by hMSC injection by enhancing neuron differentiation in vivo (Fig 8B G).
Inactivation of PcG by EZH2 knockout in ESCs markedly enhances neuron differentiation during neocortical development, demonstrating a role for EZH2 in the regulation of neural precursor cells' fate (Hirabayashi et al, 2009).
In both MS and EAE, VEGF acts as a pro-inflammatory factor in the early phase but its reduced responsivity in the late phase can disrupt neuroregenerative attempts, since VEGF naturally enhances neuron resistance to injury and regulates neural progenitor proliferation, migration, differentiation and oligodendrocyte precursor cell (OPC) survival and migration to demyelinated lesions.
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