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Groups of mice were vaccinated with 100 µg of MBP-C5a or PBS emulsified in CFA, s.c. on day −21 and revaccinated on days −10 and −2 with 50 µg of MBP-C5a or PBS emulsified in IFA s.c. A cocktail of the 3 mAbs (6 mg per mouse) was injected i.v. and on day 5, LPS (25 µg/mice) was injected i.p. to enhance incidence and severity of arthritis.
It is well known that increased cancer detection activities, notably mammographic screening examinations, may enhance incidence rates (Persson et al, 1993; Wun et al, 1995; Rostgaard et al, 2001).
Coupling of TgPTTG with mutant p53 led us to conclude that the early neoplastic events (normal to dysplastic) were independent of p53 as the additional mutation did not enhance incidence of ovarian cancer; however overexpression of PTTG and loss of p53 function reduced the time of development of certain cancers, including sarcoma.
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Moreover, patients with high levels of macrophages in TIF showed a significantly enhanced incidence of local tumor recurrence (ρ = 0.0001).
Nanowires may possess good antireflection properties for solar cell applications because the subwavelength scale of nanowire arrays will strongly scatter incident light and has a graded refractive index, which may enhance the incidence of light in usable wavelength range.
Deficiencies in factors that regulate the DNA damage response enhance the incidence of malignancy by destabilizing the genome.
When miR-92a is overexpressed, blood vessel growth and functional recovery of damaged tissue are restricted [31], which may enhance the incidence of pulmonary edema and ARDS.
Although PAH is a relatively rare disease, many genetic risk factors can substantially enhance its incidence and prevalence with an increased mortality (Peacock et al., 2007; Schermuly et al., 2011; Mehari et al., 2014).
Likewise, a 50% reduction in Hsp70 gene copy number did not enhance the incidence of mwh LOH observed in Mnn1 deletion mutants under heat shock conditions.
These results raise concern that the increasing global burden of COPD will further enhance the incidence of active TB especially in settings with a high burden of latent TB.
Since our incidence of tumor formation was ~17%, we cross-bred our TgPTTG mice with p53 mutant (p53+/−) mice with the assumption that p53+/− would enhance the incidence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com