Interferons (IFNs), which are widely used for the treatment of neoplasias and viral diseases, enhance expression of several cell surface molecules both in vitro and in xenograft tumor models [8], [9].
PRIMA-1 and its structural analog PRIMA-1Met (APR-246) refold mutant p53, enhance expression of several TP53 targets, including Bax, Puma and Noxa, and inhibit human tumor xenografts in SCID mice and mouse tumors in syngeneic hosts.
Given that FASX enhances expression of the secreted virulence factors streptokinase (Ska) and streptolysin S (SLS), and reduces expression of several extracellular matrix binding proteins, the variation in FASX transcript levels among clinical isolates may impact their virulence potential [15].
When examining melanoma cell lines, C646 interfered with the expression of several genes involved in cell cycle regulation, DNA damage repair, and nucleosome assembly, while enhancing expression of the tumor suppressor protein p53.
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.
We demonstrate here that CXCL12 can enhance the expression of several growth factors associated with angiogenesis when transduced into PDLSCs.
This is in line with experimental evidences suggesting that chronic oxidative stress and oxidant injury may enhance the expression of several nuclear mitochondrial biogenesis genes [ 34, 35].
There are several studies showing that polyphenols have the potential to activate Nrf2 and in turn to enhance the expression of several antioxidative and cytoprotective genes in the small intestine [ 30, 31].
Our current results suggest that RA-triggering factors, such as IL-1β and HIF-2α, enhance the expression of several chemokines in chondrocytes, including Cxcl1, Cxcl2, Cxcl5, Cxcl10, Ccl2, Ccl5, and Ccl7.
In human mononuclear cells, (BCG + HBV) enhanced mRNA expression of several genes including CSF2, which contributed to clustering of genes by vaccine treatment via principle component analysis.
