Alternative methods, beyond traditional machine learning approaches that assume training and test sets from the same dataset/domain, would be necessary to generalize predictions and enhance biological conclusions.
However, it is more relevant in the case of motor and neuromuscular deficits to enhance the conclusions obtained from spontaneous activity measurements, and other approaches (accelerating rotarod, grip strength, vertical pole, etc. to put some examples) may be more informative.
Even though some mRNA granules localize less well with the puromycin signal than others and hence we cannot formally rule out that some of the mRNA granules contain translationally repressed mRNAs, these data do further enhance the conclusion that mRNA translation can occur in mRNA granules containing the PDC1 and ENO2 mRNAs.
The use of metabolomics and transcriptomics in combination greatly enhanced the conclusions which could be drawn from the dataset by aiding the interpretation of metabolomic data and by linking changes in gene expression to measured changes in metabolism.
The collection of additional data would enhance the confidence of conclusions regarding M-NCAS performance.
In the future, collecting epidemiologic information on the consumption or handling of specific retail meat products on subjects with drug-resistant or genetically related K. pneumoniae would enhance the phylogenomic-based conclusions reached by Davis and colleagues.
This paper offers a number of improvements that may enhance the believability of conclusions, particularly an individual-based structure which allows tracking of within-host immune dynamics, allowing the duration of exogenous boosting to be fitted rather than largely assumed.
We fully agree with this reviewer and the similar comment from Reviewer #3 that additional assessment of other human cells would enhance the impact and conclusions from our study.
To the degree possible, an effort was made to select a sample diverse in ethnicity, gender, and age in order to produce the maximum variation among participants so as to increase the robustness of the conclusions and enhance the likelihood of transferability to other groups or individuals.
In conclusion, to enhance the parallelized PF, the studies in [7 11] focus on the modification of the resampling operation.
