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In the context of Synthetic Biology, our model guided re-engineering framework can be applied to existing topologies with the aim of turning them into oscillators or switches.
Author's response: As explained in the comments to dr. Poole's review, I use a predictive engineering framework that can be tested by investigating whether it is biochemically and biophysically feasible.
Applying a proposed framework can guide engineering managers to redesign supply chain process according to value metrics.
This paper focuses on understanding the phenomena, and on developing a predictive capability that can form the engineering framework for maintaining continued airworthiness.
Both of these examples show that simple modular domain recombination can generate functional synthetic protein switches to rewire cell signalling and how a modular framework can facilitate the engineering of such protein switches.
The application of FSA under the flux balance framework can identify novel metabolic engineering targets from the metabolite-centric perspective.
The proposed performance-based approach for the analysis of a fire following an earthquake can be considered an extension of the Pacific Earthquake Engineering Research PEERR) performance-based earthquake engineering framework and used by engineers to assess structural performance under the multiple hazards.
Overall, the proposed knowledge-based systems biotechnology framework can further accelerate mammalian cell-line engineering in a targeted manner.
It is found that the proposed genetic algorithm based multi-objective framework can be implemented to multi-dimensional engineering problems to obtain the Pareto-optimal set.
The existence of such a reusable framework can significantly shorten the lifecycle of developing AR engineering applications.
It is found that the framework can effectively support learning module development in manufacturing engineering education.
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