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We have developed a system called AutoSlog that addresses the knowledge-engineering bottleneck for a task called information extraction.
However, most knowledge-based NLP systems rely on a domain-specific dictionary of concepts, which represents a substantial knowledge-engineering bottleneck.
Increased understanding of the host organism biology has suggested engineering strategies targeting bottlenecks in transcription, translation, protein processing and secretory pathways, as well as cell growth and survival.
Xbp-1-based engineering of secretory bottlenecks was compatible with a variety of different promoter product gene configurations suggesting that Xbp-1 induces generic production increases in CHO-K1 cell derivatives.
It has played a significant role in metabolic engineering by identifying bottlenecks and critical flux distributions at metabolic branch points [ 3- 8].
Poor process control strategies or a general lack of control engineering are often the bottleneck, impeding a systematic experimental approach.
Our results demonstrate a powerful strategy for applying systems biology methods to rapidly identify metabolic engineering targets and overcome bottlenecks in performance of engineered strains.
This approach has previously been shown to overcome bottlenecks in engineering of heterologous pathways and to improve sugar utilization in S. cerevisiae engineered for pentose fermentation [ 22, 23].
This historical background is a starting point for an in-depth analysis of patents, in search of information about technological direction, technical bottlenecks, and engineering heuristics.
Genetic engineering to eliminate these bottlenecks is the logical path towards establishing a strain capable of producing sensitive heterologous proteins.
Today, the stable transformation of different oilseeds crops with multiple genes is not the technical barrier; rather issues around endogenous acyl-exchange have caused bottlenecks for engineering plants to produce high levels of n-3 LC-PUFAs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com