Sentence examples for engineered trail from inspiring English sources

Thus, more potent TRAIL death receptor-targeting reagents, such as oligomerized TRAIL, TRAIL fusion proteins with the capability to anchor to the cell surface or engineered TRAIL death receptor antibodies with high affinity for Fc γRIIb may have the potential to elicit improved anti-tumor activity, but this may come along with a risk for so far not recognized side effects.

In addition, engineered variants of TRAIL, containing specific amino acid changes leading to specific targeting of TRAIL-R1 or TRAIL-R2 have been designed and have shown improved anti-tumour effects in-vitro and in-vivo when compared to wild-type TRAIL [ 22– 27].

In bacterial cultures, immunoblots for TRAIL protein showed that engineered S. typhimurium produced TRAIL that was predominantly secreted into the media supernatant and only minimally retained in the bacterial cytoplasm.

We're not talking trammeled, double track; we're talking artfully engineered, sustainably built serpentine trail that flows with the natural landscape.

In addition, engineered variants of the TRAIL protein, containing specific amino-acid changes leading to specific targeting of TRAIL-R1 or TRAIL-R2 have been developed and have shown enhanced antitumor properties in vitro and in vivo.

In the present study, we engineered Tet-On Jurkat-TRAIL cells, which exhibit strong overexpression of TRAIL mRNA and cell surface protein upon induction.

After irradiation, engineered S. typhimurium secreted TRAIL, which caused caspase-3-mediated apoptosis and death in 4T1 mammary carcinoma cells in culture.

We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma.

In addition to the wild-type TRAIL construct (sTRAILwt), we engineered constructs expressing three different DR4-specific sTRAIL variants (termed sTRAILDR4 1, sTRAILDR4 2 and sTRAILDR4 3) and two specific for DR5 (labelled sTRAILDR5 1 and sTRAILDR5 2).

Consequently, when we generated MSCs that secreted TRAIL-R2-specific variants of soluble TRAIL (sTRAIL), we found that such engineered MSCs, labeled MSC.sTRAILDR5, had enhanced antitumor activity in combination with 5-FU when compared with MSC.sTRAIL.

He wants no part of this trail of blood, of CIA engineered coups, of wasted resources.