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Surrounding the neuron are inhibitory axons or fibers (labeled in blue) that are genetically engineered to release GABA when activated by light, a technique known as optogenetics.
The nanoparticles were engineered to release the siRNA payload at a faster rate than the doxorubicin once they reach the tumor sites.
TRUCKS (T cell Redirected Universal Cytokine killing) are engineered to release IL-12 with the intent to mitigate the tumor microenvironment hostile activity.
Delivery of exogenous BDNF either via intrathecal infusion or via mesenchymal stem cells engineered to release BDNF similarly enhance recovery.
The suture's coating has been engineered to release its active ingredients locally during the first few days following surgery.
Heteropolymer gels can be engineered to release specific molecules into or absorb molecules from a surrounding solution.
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While deployment has become more advanced and is no longer closely tied to weekly cycles, for the most part this is still the system in place today, and the drive of the ops team continues to be towards making it faster for engineers to release their code (though with some important safeguards).
The cell pellet was resuspended in Opti-MEM supplemented with 5% baby hamster kidney cell TPO-conditioned media (baby hamster kidney TPO cells engineered to constitutively release TPO were a kind gift from Prof. Kenneth Kaushansky, UCSD, San Diego, CA, USA) [30].
"Instead of being dependent on the body to naturally shed biomarkers, you're sampling the site of interest and causing biomarkers that you engineered to be released," says Gambhir, who was not part of the research team.
Delayed release dosage forms such as Asacol® employ coatings that are engineered to breakdown and release the drug topically at the nominal pH of the lower intestinal tract.
Although removing the S tag did not change the oligomeric state of the fusion protein, deletion of the vector-encoded thrombin site allowed the fusion to be cleaved at the engineered site to release LL-37.
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