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What are some ways the GlobalFlyer has been engineered to overcome the inherent challenges involved in its planned flight?
Although often engineered to overcome the numerous barriers that exist in the systemic circulation, many nanocarriers fail in extending the circulation time of the siRNA.
The Absorb everolimus-eluting bioresorbable vascular scaffold (AbsorbBVS) is a completely resorbable device engineered to overcome the limitations of permanent metallic stents, providing temporary scaffolding and antiproliferative drug delivery for the treatment of obstructive coronary artery disease.
Recently, however, a number of groups have begun designing and utilising artificial nucleic acid probes which have been specifically engineered to overcome the limitations that natural nucleic acids (DNA and RNA) tend to have; specifically their rather poor specificity and affinity.
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Drug-delivery systems have been engineered to overcome these obstacles by preserving therapeutic bioactivity and enabling spatiotemporal control over delivery.
These approaches exploit the electrophilicity of metal π-allyl intermetal π-allylhave been elegantly engintermediatesercome significand chaveenges, including elimination to form dienes, the reversibeenty of C–F bond formation,[ 15] and relegantlytivity (formation of branchengineeredar allylic fluorides).
The nitroarene dioxygenases will serve as catalysts for direct synthesis of highly substituted catechols, however, the reaction conditions must be engineered to overcome product toxicity and allow sustained accumulation of catecholic products.
Guided by the ProTide technology, these agents are engineered to overcome cancer-cell evasion and resistance.
Pichia pastoris strains have been re-engineered to overcome this undesired glycan modification [ 5].
Recently, the use of CAR-modified CTLs to target cancer has become a promising approach for cancer immunotherapy and represents a broad-based approach by which T cells can be engineered to overcome antigen restriction or mutation (Wang and Wang, 2017).
This Pfu DNA polymerase mutant was engineered to overcome uracil stalling.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com