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Mutagenic transposons have been engineered to be capable of inducing both gain- and loss-of-function mutations, allowing efficient identification of oncogenes and tumor suppressors, respectively.
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We have developed a family of potent fluorescent PI3Kα inhibitors in which part of the fluorophore was engineered to be a pharmacophore capable of inhibiting PI3Kα.
Herein, we show that Hipp is capable of reversing drug resistance in tumors engineered to be dependent on PI3K/AKT/mTOR signaling.
And it may be because chickens that have spent all the early part of their lives in a building are effectively engineered not to be capable of going outside.
Therefore, solar energy engineers need to be capable of extracting the real V–I characteristics of any PV module in order to accurately assess a system's performance and troubleshoot potential problems.
Our minicellulosome is the first engineered enzyme system confirmed by test to be capable of both operating at temperatures as high as 60°C and converting over 60% of crystalline cellulose to fermentable sugars.
To be successful as an engineer, it is therefore increasingly important to be capable of dealing with economic issues, be they in development or management.
They tend to be capable but uninspired.
It might be feasible to extend the CLL therapy [ 1, 2] to other B lymphocytic neoplasms, as similarly engineered CTL should be capable of attacking any CD19-positive cancer cells.
Viral vectors engineered to target PGE2 were capable of overcoming localized immunosuppression leading to profound changes in the tumor's immune status.
The economic rebalancing Beijing is trying to engineer is capable by itself of achieving the country's energy-intensity and carbon-intensity reducing goals.
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CEO of Professional Science Editing for Scientists @ prosciediting.com