Sentence examples for engineered point from inspiring English sources
The stability of the introduced mutations was further checked in viruses recovered from latently infected spleens confirming the retention of the engineered point mutations.
This approach was used effectively to test an engineered point mutation in an Arabidopsis thaliana (L).
To assess the importance of these same residues for cell viability in Gpn2 and Gpn3, we engineered point mutations at the orthologous sites via site-directed mutagenesis.
In 2002, investigators from the laboratory of Hirano reported that a genetically engineered point mutation in the IL-6 family receptor signalling subunit gp130 was sufficient to induce an autoimmune arthritis [ 3].
Engineered point mutations in loop 1 (E409K and G410K) are shown to destabilise the dimer interface, lead to a higher proportion of the bound monomer and, in NF-κB luciferase reporter assays, are associated with reduced NF-κB activity compared with wt-p62.
Furthermore, mice expressing an engineered point mutation in the Nrp1 extracellular region (Y297A) that abrogates Vegfa binding do not develop obvious brain pathologies (Fantin et al., 2014).
Furthermore, our studies of the mechanical stability of I1 modules engineered with point mutations reveal significant differences between the mechanical unfolding of the I1 and I27 modules.
Based on this observation, we engineered a point mutation (G283P) at the hinge region, in order to stabilize YscD in a less flexible conformation.
To investigate this issue we engineered a point mutation into the SH3 domain of PSD95 in mice and examined multiple forms of behavioural plasticity.
Engineered double-stranded DNA breaks can efficiently disrupt genes, or, with the right donor vector, engineer point mutations and gene insertions.
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