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This progress is evinced by the wide variety of secondary metabolite and novel products engineered for production in cells [ 14- 21].
But organisms that are engineered for production of a particular product are no longer optimal for survival, and even in closed systems would have to somehow be protected from wild competitors—something Darzins says "nobody knows anything about".
We use this framework to predict scaled up growth and product secretion in 1L photobioreactors of two strains of Synechococcus PCC7002 engineered for production of l-lactate or L-lysine.
Corynebacterium glutamicum has been engineered for production of the polyamide monomer putrescine or 1,4-diaminobutane.
This bacterium has been engineered for production of various non-native cyclic C40 and C50 carotenoids such as β-carotene, astaxanthin or sarcinaxanthin.
Cyanobacteria engineered for production of biofuels and biochemicals from carbon dioxide represent a promising area of research in relation to a sustainable economy.
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Many lead compounds in the search for new drugs derive from peptides and polyketides whose similar biosynthetic enzymes have been difficult to engineer for production of new derivatives.
The biosynthetic pathways for isoprenoid production have been extensively studied and engineered for microbial production of flavors, fragrances, drugs, and more recently for the production of biofuels.
To date, their heterologous biosynthesis in microorganisms has been achieved only by precursor feeding or as minor by-products in strains engineered for flavonoid production.
Although Lactobacillus casei[ 110] and Lactobacillus plantarum[ 111] were also engineered for sorbitol production, sorbitol with a yield up to 0.65to 0.67 mol/mol glucose [ 111, 112], the conversion rate of sugar and yield of sorbitol are lower when compared to Z. mobilis.
Corynebacterium glutamicum, which is used for l-lysine production in the million-ton-scale, was engineered for ectoine production by heterologous expression of the ectoine biosynthesis operon ectABC from Chromohalobacter salexigens.
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