Sentence examples for engineered factors from inspiring English sources

Our studies not only establish a rapid and highly efficient iPSC reprogramming system but also uncover a mechanism by which engineered factors coordinate with TETs to regulate 5hmC-mediated epigenetic control.

We introduced the engineered factors XYZK (Oct4-VP16, Sox2-VP16, Klf4 and Nanog-VP16) due to their strong promoting capability during reprogramming [ 18].

Furthermore, the use of high-performance engineered factors led to less CNVs than the classic factor(s) of the same dosage.

Based on the genome-wide analyses of 41 miPSC lines derived by different methods, we suggest that increasing factor dosages, or using high-performance engineered factors [ 18], is beneficial for the genome integrity of the resulting miPSCs.

This suggests that high-performance engineered factors XYZK are likely to help maintain the genome integrity by reducing reprogramming barriers.

In the present work, the engineered factor F3 has been co-crystallized with compound D24, a potent APN inhibitor introduced by our lab.

We do propose here now that engineered factor F3 can be employed as a reasonable alternative of hAPN for drug design and development.

Using an engineered factor VII that can be secreted as factor VIIa, viral-mediated delivery of this transgene in the mouse liver resulted in phenotypic correction of murine hemophilia B, at expression levels of ∼1 mg/ml.

Amylose affinity-purified ScFv 18-2 NLS protein was stable to storage at 4 °C in the presence of glycerol or trehalose, bound selectively to an epitope peptide, and was cleavable at an engineered Factor Xa protease site.

We found that MsrB1 with the engineered factor Xa cleavage site had some Msr activity, whereas treatment with factor Xa protease in vitro resulted in the loss of this activity (Table 1).

We describe aspects of studies at this level that influence successful DNA binding of engineered transcription factors, thereby affecting gene activity.