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The rFVIII protein has been engineered extensively throughout the years to increase the low production yields that initially were obtained from mammalian cell cultures.
These processes have been engineered extensively, with valine and lysine production titers reaching ∼100 g/L (Leuchtenberger et al. 2005).
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Architects and structural engineers extensively perform designs of buildings with steel and reinforced concrete materials that, to different degrees, are energy intensive.
I spoke with a Range Rover engineer extensively about the lack of options and apparently a committee decided to limit the amount of customization.
CP is the first example of an extensively engineered disaccharide phosphorylase, and may provide valuable information for protein engineering of other phosphorylase enzymes.
The Caloosahatchee has been extensively engineered to assist river traffic.
This bacterium was extensively engineered to create a suitable host for polyketide production.
Previously, these engineered tubes became extensively recellularized following implantation into the sheep femoral artery.
It could also have applications in the dairy industry, which uses genetically engineered Lactobacillus acidophilus extensively in cheese starter cultures and yogurt.
The product of this work is a yeast strain that contains an extensively engineered chromosome III, and that grows just as well as the original strain.
SpCas9 has been extensively engineered, optimized, and delivered both in vitro and in vivo using a variety of different modalities and methods10,11,12,13,14,15,16.
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