Sentence examples for engineered deficiencies from inspiring English sources

Animal models with engineered deficiencies in certain complement proteins have demonstrated that widespread complement activation after severe injury culminates in complement dysregulation and excessive generation of complement activation fragments.

To further explore the contribution of the immune cells to surveillance of senescent and non-senescent tumour cells, mice with engineered deficiencies of specific immune cells need to be used.

Moreover, hypercholesterolemic mice with genetically engineered deficiencies in proteins implicated in HDL metabolism have strongly atherosclerotic phenotypes, providing compelling evidence that HDL is a key modulator of atherosclerosis in animal models.

Although residual amounts of abnormally spliced Pink1 transcript would exist in all these Pink1 mutant mouse lines and it could be speculated that residual amounts of PINK1 protein with abnormal 3' sequences are relevant, it is highly probable that mouse phenotypes would result from the engineered deficiency rather than from sequence abnormalities of residual PINK1.

Various reports have documented that either NF-kB molecular blockade [ 32, 33] or STAT-1 genetically engineered deficiency [ 34] can each protect pancreatic β-cells against cytokine-induced cell death.

Work on hereditary diseases and murine models with engineered genetic deficiencies in glycosylation has revealed ample connections to apparent dysfunctions [ 2, 3].

This gene was already associated with autophagy, and in both studies, mice engineered with deficiencies in the Atg16L1 gene displayed gut inflammatory phenotypes not previously associated with autophagy.

In contrast, preparations of wild-type NP purified in high salt concentrations as well as mutant Y148A engineered for deficiency in nucleic acid binding were partly or totally oligomeric in RNA-free solutions.

Despite its apparent importance in hydrogen peroxide removal, humans with genetic deficiency of catalase — "acatalasemia" — or mice genetically engineered to lack catalase completely, suffer few ill effects.

Recombinant wild-type NP purified in low salt concentrations and a derived mutant engineered for oligomerization deficiency (R416A) were mainly monomeric in RNA-free solutions as shown by biochemical and electron microscopy techniques.

Researchers who examined mice genetically engineered with orexin deficiency found that these mice were heavier than normal mice, despite being fed a more restrictive diet.