Major histocompatibility complex (MHC) class I molecules can be engineered as single chain trimers (SCTs) that sequentially incorporate all three subunits of the fully assembled proteins, namely peptide, β2 microglobulin, and heavy chain.
Engineered biofilms comprising a single recombinant species have demonstrated remarkable activity as novel biocatalysts for a range of applications.
"A warehouse of super computers," he declared, could not engineer a single microorganism as elegantly as the basic operation of natural selection.
Yet, each ERE sequence, when cloned as a single copy, or when engineered as two tandem copies of the ERE-containing sequence, was not capable of activating a luciferase reporter construct in response to E2.
This review focuses on environmental implications and applications of engineered magnetite (Fe3O4) nanoparticles (MNPs) as a single phase or a component of a hybrid nanocomposite that exhibits superparamagnetism and high surface area.
We engineered the sgRNA to be produced as a single RNA molecule by fusing the crRNA and tracrRNA, as previously described33.
Such satellites have enabled scientists and engineers to treat the planet as a single thing in a way that they previously did not.More subtle and just as far-reaching was the message epitomised during the next leg ofar-reaching was when the crew of Apollo 8 photographed Earth-rise over a lunar horizon on Christmessage, 1968.
In simple terms, metamaterials are specially engineered surfaces that have embedded microscopic structures and work as a single device.
To determine whether MELK has a transforming activity as a single event in this system, we engineered Rat1-DD cells expressing MELK (Rat1-DD-MELK), or PI3KCA H1047R (Rat1-DD-PI3KCA H1047R) as a positive control.
The study also corroborates the general applicability of engineered HJs as single-molecule reporters for protein-DNA interactions, which are fundamental processes in gene replication, transcription, recombination, and regulation.
