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To understand the structural role of P0 in myelin membrane adhesion and its mechanism of action, a model system should be developed in which alterations in P0 can be engineered and introduced transgenically into an animal, and in which ramifications across the hierarchy of myelin development, nerve function, and myelin membrane structure and interactions can be determined.
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In the last decade spectral variants of these proteins have been cloned or engineered [2], and introduced in transgenic animals either to report neuronal activity [3] [9] or to label neuronal subsets [10] or subtypes [11].
Repair templates can be engineered, however, and introduced into cells to make a defined genomic modification via HR (GT).
"At a meeting, I led the oil dipstick engineer over to the transmission fluid dipstick engineer and introduced them.
The 19th-century British presence is still on display in the Bellavista neighborhood, where the mine's owners built homes and a clubhouse for managers and engineers, and introduced Spain to sports like tennis and golf.
The ease with which plasmids are isolated, genetically engineered, and re-introduced has led to their near ubiquitous use in synthetic biology, despite the potential consequences of variable copy number.
The change underscores the steps tech companies are taking to engineer serendipity and introduce us to ideas we might not have discovered otherwise.
The goal is to break the old stereotype of nuclear engineers and introduce the public to today's nuclear scientists and engineers — young, diverse, and as Steve Jobs would say, "insanely great".
Taking a page from how the NBA starts scouting recruits when they're still in high school, Partovi, 46, would identify the most brilliant young engineers and introduce them to his network of technologists, from Facebook CTO Mike Schroepfer to Stripe cofounder John Collison.
Matthew Boulton, (born Sept. 3, 1728, Birmingham, Warwickshire, Eng. died Aug. 17, 1809, Birmingham) English manufacturer and engineer who financed and introduced James Watt's steam engine.
September 3, 1728 Birmingham, England August 17, 1809 Birmingham, England Matthew Boulton, (born Sept. 3, 1728, Birmingham, Warwickshire, Eng. died Aug. 17, 1809, Birmingham), English manufacturer and engineer who financed and introduced James Watt's steam engine.
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