After an elaborate planning, even an extensive drug testing program can be executed without substantial setbacks.
Sessions will engender substantial controversy if he focuses federal enforcement on street crime and neglects white-collar prosecutions.
Yet there have been substantial setbacks.
However, there have also been substantial setbacks -- ranging from discriminatory legislation, to impunity for brutal violence against lesbian, gay, bisexual, transgender, and intersex (LGBTI) people.
A primary implication of this simple inference is that extremely strong, early selection can favor alleles that benefit early survival even if they engender substantial health and fitness costs later in life, owing to pleiotropy and linkage disequilibrium.
Thus, the borderline statistical significance of group differences between AMD and controls may reflect the fact that some of our AMD group had a level of vision loss (mean better-eye VA = 20/48) insufficient to engender substantial fear of falling.
"That was a substantial setback for Vitro and a substantial victory for the holdouts".
While these tactics conformed to the national government's political priorities, they were a substantial setback for municipal Shanghai's global aspirations.
Last year the law suffered its first substantial setback when state courts upheld the positions of Glastonbury, Newtown and Bridgewater against developers.
Staff members for two American senators, one Democrat and one Republican, said all was not lost, however, despite the substantial setback.
The judgment is a substantial setback for the prime minister, Theresa May, who wants to set the exit process in motion by March.
