Cumulatively, however, such minor effects may engender disease-associated haplotypes that contribute to population-level variation in PRE occupancy (e.g., by AP-1), which is in turn connected to susceptibility through its influence on the expression of genes promoting normal KC differentiation and barrier function (Figure 8B).
However, the resistance of the mouse to spontaneous atherosclerosis is a significant barrier, and standard mouse models of atherosclerosis require major perturbations of cholesterol homeostasis and inflammation to engender disease progression.
The fledgling Christian Science movement was further threatened by internal schism and the rivalry of various "mind-cure" groups that appropriated her terminology but sought healing not through divine help but through the powers of the human mind, which she saw as engendering disease in the first place.
Even though the mechanisms by which the virus engenders disease are not yet completely understood, numerous evidences indicate the multifunctional Tax protein as essential for malignant transformation (reviewed in [ 9]).
Announced with fanfare by then-President Bill Clinton and British Prime Minister Tony Blair in 2000, the mapping of the human genome was expected to reveal the root genetic causes of diverse, serious diseases, and engender therapeutic insights, targeted treatments and elusive cures.
Staphylococcus aureus is an ubiquitous bacterium and is a part of the human skin and mucosal flora, it can engender a variety of diseases and it is one of the most common causes of hospital infections.
As an accompaniment weak tea with perhaps a little sugar, milk or spirits is universally drunk... such a way of living unavoidably engenders a multitude of diseases".
Furthermore, the recognition of a patient with an exotic or unfamiliar contagious disease may engender trepidation among the medical community as well as the public.
Future research will focus on validating the effects of these candidate genes and their functional variants using genetic transformation and transferred DNA insertion mutant screens, to verify that these genes engender resistance to blast disease in rice.
