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Whereas αβTCRs have lower affinities and recognize processed peptide antigen expressed in the context of major histocompatibility complex (MHC), CARs are high affinity, MHC-unrestricted and capable of engaging target cell surface proteins independently of presentation pathways (Sadelain et al, 2013).
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Army manuals and drill sergeants speak of "suppressing enemy fire," "engaging targets," and "attritting" the enemy.
I told the United States, if drones are so accurate in engaging targets, why don't you give them to us?
Flown by a crew of two, a pilot and an air combat officer (ACO), it is capable of engaging targets in the air and on the surface simultaneously.
"This allows companies to orchestrate multi-step plays that engage target accounts across departments and channels, including email, phone, social, and demand generation".
These data demonstrate that the KIR+ and NKG2A+ subsets within the UCB-derived NK cell products are fully responsive mediating strong degranulating activity, which is regulated by the expression of MHC class I molecules on the engaged target cells.
The success of a screening programme depends on how well it engages target groups [ 19], whose health beliefs and perspectives are likely to affect acceptance and uptake.
One of the biggest strengths of the project was the participatory planning approach that engaged target communities in identifying key development challenges in their areas and in determining the activities that were most contextually suitable to addressing these problems.
The necessity to complete 3′-processing may restrict the ability of incompletely assembled viral nucleoprotein complexes to engage target DNA and perhaps reduce the chance of suicidal auto-integration.
With KSHV and other herpesviruses alike, envelope glycoproteins have been widely reported to physically engage target cell surface receptors, such as integrins, in interactions leading to entry and subsequent infection.
When introducing new technology for the purposes of QI, it is important to explore entrenched stakeholder belief systems using exploratory methods and engage target users before applying incremental changes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com