Sentence examples for engaging substrates from inspiring English sources

Protomer A is allosterically uncoupled but possesses a free SBD capable of engaging substrates (or other BiP molecules through their interdomain linker).

The model fits the observation that oligomeric forms of Hsp70 are holdases rather than foldases (Blond-Elguindi et al., 1993; Thompson et al., 2012), as the only protomer capable of engaging substrate (protomer A, Figure 1C) is allosterically uncoupled by the engagement of its interdomain linker in the SBD of the adjacent protomer.

The results show that local and global processing within pitch sequences differentially engage substrates in the posterior STS and that additional neural resources are required in the right posterior STS and PT for local pitch change processing.

The latter was much diminished when BiPADDA was replaced by the compound mutant BiPADDA V461F, which is unable to engage substrate.

These motions in turn drive axial movement of loops lining the hexamer pore (pore loops), which contain aromatic residues that directly engage substrate proteins during unfolding (Siddiqui et al., 2004; Iosefson et al., 2015).

In the past three years, several polynucleotide ligases have been crystallized in complex with nucleic acid, providing the introductory views of ligase enzymes engaging their substrates.

Our structural and biochemical data suggest that Pch2/TRIP13 engages its substrates within the hexamer pore, and undergoes coordinated ATP hydrolysis-coupled conformational changes to mediate substrate unfolding.

Given that p300 is known to acetylate more than 70 different protein substrates with somewhat diverse sequence characteristics flanking the cognate lysine residue, it is possible that p300 does not engage all substrates similarly.

How the CMG is assembled and engages DNA substrates remains unclear.

The disordered linkers may allow Rad23 to present proteins of different structures and ubiquitination patterns to the proteasome such that the ATPase motors can engage these substrates.

DOI: http://dx.doi.org/10.7554/eLife.08961.016 Native gel electrophoresis confirmed the presence of discrete higher molecular weight species of BiP in cell lysates, which stand out above the heterogeneous signal expected of a chaperone that engages many substrates [as previously noted, (Freiden et al., 1992)].