Sentence examples for engaging downstream from inspiring English sources

While subtle differences in the binding properties of each of the interferons to IFNAR, their common receptor, have been predicted based on analysis of their amino acid sequence and mutation studies, and there are demonstrated differences in engaging downstream signaling components by the two type I interferon subtypes, their functional impact on gene expression is quite comparable [ 32- 34].

Background: The mammalian Grb2 adaptor protein binds pTyr-X-Asn motifs through its SH2 domain, and engages downstream targets such as Sos1 and Gab1 through its SH3 domains.

The ability of these GTPases to signal requires that the GTP-bound form engage downstream effectors, interactions that occur only on the cytosolic surface of cellular membranes.

Visuomotor circuits filter visual information and determine whether or not to engage downstream motor modules to produce behavioral outputs.

POMC and NPY/Agrp neurons engage downstream targets, such as in the paraventricular hypothalamic nucleus, that possess the melanocortin receptor (MC4R).

Class IA PI3Ks catalyze the synthesis of the lipid second messenger phosphatidylinositol (3,4,5 -triphosphate (PIP3,4,5 -triphosphateownstream effectors such as the PIP3ein kinase B (PKB) pathwhichShengageset al., 1998; Vanhaesebroeck et al., 2005).

CLEC12A is a C-type lectin receptor (CLR) belonging to a family of transmembrane proteins that recognize pathogen-associated molecular patterns and engage downstream immune signal transduction pathways (Dambuza and Brown, 2015; Osorio and Reis e Sousa, 2011).

On the other hand, phase-advanced photoentrainment in Six3-Cre Lhx1lox/lox mice, with an activity onset before dark, suggests that the Lhx1-deficient SCN does engage downstream oscillators when driven by light.

Four adaptor proteins (myeloid differentiation factor (MyD 88, MyD88-adaptor-like/TIR domain-containing adaptor protein (MAL/TIRAP) [ 7], TIR domain-containing adaptor inducing interferon-β (TRIF) and TRIF-related adaptor molecule (TRAM) [ 8, 9]) transduce signals from all of the TIR domains and engage downstream signaling proteins.

Our investigations suggest that GRASP65 cleavage contributes to apoptotic signalling via release of membrane distal caspase cleavage fragments that translocate to the mitochondria and engage downstream execution phase processes, and we identify Bcl-XL as a candidate apoptotic GRASP65 binding partner.

In order to identify other signaling molecules that might be engaged downstream of TLR5 in the absence of MyD88, we initially probed a Kinex antibody microarray containing a panel of phospho-specific antibodies to provide a broad overview of intracellular phosphorylation.