Through clustering analyses, we noticed that the adhesion-related crosstalk between PML and TNF α engages a complex molecular mechanism.
These molecules are ligands that engage a complex composed of type I receptor and type II receptors to initiate intracellular signaling.
Once the receptor is engaged, a complex is formed between MyD88, TRAF6, IRAK4, and IRAK1 that allows for activation of IRF [ 22, 23].
The two enzymes can be activated independently, but only together do they engage a complex transcription program that results in suppression and apoptosis of T cells.
Cytochrome c engages a complex containing Apaf-1 and caspase-9 that in the presence of ATP forms a large molecular weight complex of active caspase-9 known as the apoptosome (Cain et al. 2000).
Take, for example, the use of 'outcomes' to describe changes in health, wellbeing and health-related behaviours in the context of someone with long-term illness engaging in a complex intervention – such as someone with arthritis and depression engaging in group exercise such as Tai Chi.
Specificity may lie rather in the recruitment of particular combinations of subunits, such that chemotropic BMPs engage a receptor complex whose composition is distinct from complexes mediating inductive responses evoked by a majority of BMPs (Figure 8).
Paradoxically, Invisible Children is also being attacked from the other side entirely, by people saying that the campaign excuses people from engaging with a complex issue in a serious way, calling it "dumbing down" and accusing the makers of being naive.
In addition to engaging in a complex assessment of alternative consequences, participants provided lengthy commentaries on the cultural appropriateness of particular landscape conditions, and conceptions of landscape care or 'visible stewardship'.
These effector cells are highly efficient at killing phagocytosed pathogens by engaging in a complex cascade of cellular events involving multiple defense mechanisms to eradicate bacteria.
