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As a cell engages the surface it will bind to a finite number of integrins and apply an initial force at a few sites.
A crystal structure obtained for the binary complex of PPP1R15B and PP1 demonstrated that the N-terminal half of PPP1R15's functional core extensively engages the surface of PP1 following an itinerary previously observed for the regulatory subunit PPP1R9/spinophilin (Ragusa et al., 2010; Chen et al., 2015).
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This spider-like device will then hope to engage the surface at "walking pace", deploying screws and harpoons in an effort to lock itself down to an object that has very little gravitational attraction.
Let me repeat that not only was he following this aircraft, and was he concerned about it, he was engaged on the surface with Iranian units at the time.
The mid-nineties were years that seemed politically engaged on the surface.
The gecko can also choose to keep the tips of its toes curled up as it runs, keeping the setae from engaging with the surface it's running on, but that reduces the amount of foot it's able to use while running, which also affects its speed.
The mid-nineties were years that seemed politically engaged on the surface, but the general tenor of youth culture was apathetic and ironic, and middle class kids who had no reason beyond their youth to feel alienated copped a pose of bored disaffection.
The probe is then brought to a contact, engaged with the surface of interest.
Exposure to exogenous CLCA1 increases cell surface levels of TMEM16A and cellular binding experiments indicate CLCA1 engages TMEM16A on the surface of these cells.
These results indicate that N-CLCA1 engages TMEM16A on the surface of HEK293T cells, and suggests that the enhanced TMEM16A level is a consequence of stabilization by CLCA1.
gB-NT is presumably displaced from gH/gL after virions engage the cell surface.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com