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We show that rather than binding to the main ATPase site within dynein's AAA+ ring or its microtubule-binding stalk directly, Lis1 engages the interface between these elements.
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Once the conversation is engaged, the interface updates immediately in context, enabling the kinds of swarms that have grown around Gillmor Gang recording sessions.
The tubulin dimer density (red) is deformed by two new densities: a TBCC wedge shaped density engages the Arl2 interface (green), and a second density (cyan) is wedging between the two αβ-tubulin dimer lobes (red).
In the present study, provider pairs were engaged in the interface design process during Phase I and reviewed proposed interface implementation strategies.
However, none of the alternative models engaging the catalytic interface bring the two nucleotides into atomic contact.
Fourth, Lis1 engages dynein close to the interface between these elements, at AAA3/4.
Thus, we conclude that Lis1 engages dynein at AAA3/4, near the interface between its catalytic ring and microtubule-binding stalk.
Extracellular regions of nectins engage in trans-interactions on the interface of two juxtaposed cells.
The interface is terrible.
Your body becomes the interface".
The interface blows me away.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com