Sentence examples for engagement of substrate from inspiring English sources

As this particular dimeric arrangement of SecYEG is obligatory for the productive engagement of substrate (Deville et al., 2011), we used 2D crystallography again for the complex with preprotein peptide.

The structures determined in complex with reaction products provide details of the − 1 subsite architecture, catalytic residues, and a structural change in the active site that is likely required to enable hydrolysis of the glycosidic bond by promoting engagement of the substrate by the catalytic residues.

Another case of regulated engagement of CHIP for substrate ubiquitination is provided by CYP2E1, a liver ER cytochrome P450, responsible for xenobiotic metabolism.

Engagement of a pupylated substrate into the proteasome occurs by means of the unstructured amino-terminal portion of Pup that is first threaded into the Mpa central pore and then translocated into the proteasomal degradation chamber [ 10, 33].

Thus, the kinetics of substrate engagement by a PQC factor and its partitioning during cell division impose cell-based limitations on proteostasis capacity.

We believe that establishing these points represents a significant advance in the field because up until this point, the engagement of chaperones with substrates has been correlated with reduced, not enhanced, activity.

The engagement of Hsp104 with these substrates, and its inability to resolve them before cell division, leads to asymmetric retention of the chaperone in cells that experienced the thermal stress.

The large difference in the position of the thumb domain in the ternary complex and in the isolated polymerase suggests a molecular basis for the release of the completed primer-template by Pol α: loss of the interactions with the primer-template duplex would allow the thumb domain to rotate away from the DNA, terminating the productive engagement of the polymerase with its substrate.

In order to release the polypeptide from the hsp70-substrate, taking into account the high affinity of HSP70 to the substrate in the ADP-bound state and the physiological ATP concentrations, the engagement of NEFs to the HSP70-substrate complexes is crucial.

As a result, KMD1B binds to a much longer sequence of histone H3 than KDM1A, and its activity requires engagement with both substrate and non-substrate regions of the histone tail through different protein domains.

The consequences of engagement of calpain-1 with its substrates, however, in governing the age-associated proinflammatory status within the arterial wall, remains unknown.