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These findings have important implications for rational vaccine design, where improving the generation and engagement of memory Tfh cells could be used to enhance vaccine-induced protective immunity.
The functions of the adaptive immune response include induction of more specific and stronger defence mechanisms against abnormal stimuli, and engagement of memory T cells that can recognise and eliminate the same stimulus more quickly and efficiently if it is encountered again in the future.
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Engagement of the memory and an adaptive compensation of eye displacements may be the reason why even though there is continuous eye jitter, our vision is perceived perfectly clear and stable [ 19].
It is a demonstration of long term correlations and negates the randomness (at which the new event has no relation with the previous events) in the eye movements, signalling also engagement of the memory.
One possibility is that the posterior cingulate activity observed in the present study reflects engagement of such memory processes when participants observe sequences associated with either PVA or VA experience.
Our data indicate that SWDs are not a reliable surrogate marker of appropriate target engagement for reversal of memory dysfunction in APP/PS1 mice.
Research has also shown engagement of pitch working memory processes by less expert musicians associated with activation of right dorsolateral prefrontal cortex (Zatorre et al. 1994).
In experiments 3 and 4, we explored the robustness of cortical feedback to interference with orthogonal engagement of attention, working memory, and visuospatial processing.
In other words, the engagement of pitch working memory structures at relatively high processing load provides a potential neurocognitive marker of lower AP skill (cf. Münte et al. 2002; Ross et al. 2004).
In summary, we demonstrate a significant impairment of the engagement of a distributed working memory neural network comprising bilateral PFC, anterior cingulate, medial temporal, basal ganglia, inferior frontal and bilateral posterior parietal regions primarily occurring during stimulus encoding.
It also produced responses in the ventral posterior cingulate (BA30) at −12, −56, 12 (kE = 1514), possibly reflecting the engagement of semantic and episodic memory retrieval systems (e.g., [14]).
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