TCR engagement activates the Cn/NFAT signaling not only during the activation of mature T lymphocytes, but also at the specific steps of thymocytes development (revised in [ 77]).
To determine whether LFA-1 engagement activates T cell Rac1 and/or Rac2, and whether the kinetics of activation are consistent with rapid modulation of mRNA binding proteins, peripheral human T cells were MnCl2-treated, to promote LFA-1 affinity modulation and prime for ICAM-1 binding, after which they were adhered to rICAM-1-coated dishes.
T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and the Syk-related PTK, ZAP-70.
Since we have shown that CD40 engagement activates Nf-κB in a T cell clone [16] we determined whether CD40 could induce Nf-κB activation in primary T cells as well.
TCR engagement activates many different signaling pathways that contribute to the formation of a stable T cell-APC interaction zone or 'synapse' and lead to T-cell activation, including proliferation and secretion of cytokines [4], [39].
In addition, P2X7 receptor engagement activates several second messenger and enzyme cascades.
TCR engagement activates several CTL effector functions that contribute to antitumour immunity (Chavez-Galan et al, 2009).
Although the receptors that activate epithelial cells are not all known (Cheng et al., 2012; Weindl et al., 2010), their engagement activates the NF-κB pathway in addition to other transcription factors (Moyes et al., 2010).
Taken together, these studies raise the question whether E-cadherin and/or nectin engagement activates or suppresses Rac1 activity during initial cell-cell adhesion.
In our model, we establish that TCR engagement activates Boost from its inactive state (Boosti) to its active state (Boosta).
