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Whereas the AON target site high engaged score was expected, the higher engaged score of the AON target site compared to the AON target site was confounding.
Taken together, these results suggested that the presence of at least three consecutive engaged nucleotides at simultaneous steps of transcriptional analysis but not the individual nucleotide engaged score attenuated AON efficacy and efficiency.
The three fourth level scores were calculated only for those groups of consecutive nucleotides meeting the following criterion for analysis: every nucleotide in the group having an engaged score of at least 0.1.
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We've engaged scores of writers to contribute to the museum and created something truly unique.
It was an era when baseball card collecting engaged scores of passionate Americans, especially children.
As expected, they liked that the system seemed fair and kept them engaged: Scores were recorded in real time and calculated based on meaningful factors, and everyone (employees and managers) could see the same data.
In the mid-sixties, Morley uncorked a novel style painstakingly copying banal postcard, travel-brochure, and calendar images of ships and vacation spots or of reproduced paintings, most notably Vermeer's "The Art of Painting"—which art historians generally credit as the starting gun for Photo-Realism, a movement that engaged scores of painters in diffident imitations of the camera's Cyclopean eye.
Figure 6B illustrated an example in which the target site engaged scores (L3) correlate inversely with AON efficacy and efficiency, i.e., AON target sites with higher engaged scores had better ability to induce exon skipping.
For Set B AONs, target sites of AONs had statistically lower engaged scores than target sites of AONs.
Figure 6A illustrated an example wherein AON target sites with identical accessibility scores (L1) can have strikingly different engaged scores (L3).
The final example (Figure 6C) illustrated a widespread phenomenon in the data set in which AON target sites had higher engaged scores (L3) than AON target sites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com