When binding to the cell, the virus engaged cell-surface heparan sulfate (HS), a relatively conserved feature of the herpesvirus entry pathway [37].
Next we sought to determine how calcium triggering depended on the number of engaged cell receptors, by changing ligand density on the particle surface ρL.
The micro-bubbles engage cells or bacteria and float them into an analytical instrument.
By identifying and characterising the interaction of S100A4 with its effectors, we can supplement our understanding of how this particular clinical marker mechanistically engages cells to adopt a more motile, and thereby, more metastatic phenotype.
However, most of previous microarrayed synthetic polymers do not possess biological ligands (e.g., peptides) to directly engage cell surface receptors.
For cases where mAbs are intended to engage cell surface receptors and prevent receptor-ligand interactions (i.e., antagonists), it may be desirable to reduce or eliminate effector function for example to prevent target cell death or unwanted cytokine secretion.
Bacteria engage cell surface receptors and intracellular signaling molecules to enter the cell.
By using an optical trap, a microparticle (e.g. cell, bead) can be manipulated non-destructively and directed towards a phagocytic cell, engaging cell surface receptors to trigger the phagocytosis process.
Our previously published in vitro data are in agreement with current in vivo studies which demonstrate that resveratrol can engage cell-intrinsic pathway of apoptosis by regulating the expression of Bcl-2 family of proteins.
What upstream molecular cues instruct neurons to become mature and engage cell survival mechanisms?
