With a goal of creating living tissue prosthetics, Jonathan Butcher wants to understand how very socially engaged cells make choices about interacting with and manipulating their environment constituting a naturally engineered system.
When binding to the cell, the virus engaged cell-surface heparan sulfate (HS), a relatively conserved feature of the herpesvirus entry pathway [37].
Thymic nurse cells are the main engaged cells in the development and selection of immature T lymphocyte in the thymus.
However, most of previous microarrayed synthetic polymers do not possess biological ligands (e.g., peptides) to directly engage cell surface receptors.
The aptamer-siRNA chimera used here was previously established to specifically target EpCAM-expressing cellsr cells, undergo receptor-mediated endocytosis upon binding to target cells, and engage cell's endogenous RNAi machinery27.
For cases where mAbs are intended to engage cell surface receptors and prevent receptor-ligand interactions (i.e., antagonists), it may be desirable to reduce or eliminate effector function for example to prevent target cell death or unwanted cytokine secretion.
Bacteria engage cell surface receptors and intracellular signaling molecules to enter the cell.
By using an optical trap, a microparticle (e.g. cell, bead) can be manipulated non-destructively and directed towards a phagocytic cell, engaging cell surface receptors to trigger the phagocytosis process.
What upstream molecular cues instruct neurons to become mature and engage cell survival mechanisms?
Although the precise mechanisms have not yet been elucidated, it is possible that galectin-1 may engage cell surface glycocoproteins involved in cell motility.
