Sentence examples for engage this pathway from inspiring English sources

The discovery of microRNA-mediated cellular regulation by the RNA interference (RNAi) pathway and the possibility to engage this pathway with exogenous triggers such as small interfering RNA (siRNA) could offer a new paradigm in anti-cancer intervention with RNAi-based therapeutics.

Moreover, it seems that all live gram-negative bacteria engage this pathway (Rathinam et al, 2012).

It remains possible that in different cell systems, or in response to different signals, PUMA may also engage this pathway.

As further evidence of PUMA-mediated apoptosis, caspase-3 activation was also evaluated in p53-deficient FLS. Figure 3c shows that PUMA does not require p53 to engage this pathway.

The lack of HCN channels in the isolated neurones was also disadvantageous from another perspective, in that it would have allowed the delivery of known NO concentrations directly to the cells under study to discover the levels required to engage this pathway.

In contrast, engaging this pathway can expand anti-tumor T cells and regulatory T cells (Carreno et al., 2005).

Nevertheless, there is evidence from native neurones that the NO-cGMP pathway can also engage this target.

Inhibitory molecules, such as Sprouty proteins (SPRY) and MAPK phosphatases (MKP or DUSPs), engage the pathway at different points to negatively regulate signalling.

Disseminated cancer stem cells engage these pathways to resist the inhospitable environment at distant sites.

Failure of the host to engage these pathways results in an aberrant response and persistent inflammation (Stables et al, 2011; Chiang et al, 2012; Barnig et al, 2013).

Anticancer agents frequently engage the p53 pathway to activate the mitochondrial apoptotic pathway.