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Also P3 could be changed to Gln with no drastic change in the binding geometry as the glutamine side chain amide is able to engage the side chain of Gln192 (similar to P3 Glu).
In the first, active site docking of the SRL places its nucleophile and scissile bond in position close enough to engage the side chains of Y47 and H49.
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When using the extractor, you do not want the extractor's point to bottom out before the lands (threads) engage the sides of the hole securely.
You're not applying to be a banker or a barrister; you're engaging the side of your brain that's not burdened by budgeting or revising.
When pulled and twisted into the locked position, the edge of the lock engages the side of the plunger permitting the physician to apply even and gentle vacuum pressure while moving the cannula through the tumesced adipose layer.
"In L.A., you have to engage the entertainment side, the pop culture side," Gimelstob said.
I try to engage the other side and try to find ways we can bring the values of the kingdom of God into the experience of humanity".
The president's associates, busy lately fielding questions of what took so long, readily acknowledge that Mr. Obama could have done more over the past divisive four years to wine, dine and simply engage the other side to reach bipartisan deals on a range of issues.
Often, first responders are so busy they may forget to engage the creative side of themselves.
"I think that labor does need to engage the other side of the aisle much, much more aggressively," Maher said.
Obama tried mightily to engage the other side, and in return he is denigrated as a Communist.
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