Sentence examples for engage the pathway from inspiring English sources

Inhibitory molecules, such as Sprouty proteins (SPRY) and MAPK phosphatases (MKP or DUSPs), engage the pathway at different points to negatively regulate signalling.

Anticancer agents frequently engage the p53 pathway to activate the mitochondrial apoptotic pathway.

They further showed that Nkx3.1 was required to engage the p53 pathway, indicating that reduced Nkx3.1 expression can itself abrogate p53 signaling.

These results indicate that sustained levels of ROS generated upon Bmi-1 knockdown coupled with cisplatin treatment are sufficient to directly damage the DNA and engage the DDR pathway.

Regardless of the possible existence of other mediators of ribosome dysfunction it is striking that depletion of several r-proteins mutated in DBA (RPL11, RPL5 and RPS7) does not seem to engage the p53 pathway in different mammalian normal and cancer cell lines.

In this way, p53 may engage the lysosomal pathway without translocating to lysosomes.

Likewise, cancer cells usually engage the telomerase pathway for telomere maintenance to gain immortality.

Thus, in melanocytes with oncogenic signalling only p16INK4a can fully engage the pRb pathway to alter chromatin structure and silence the genes that are required for proliferation.

Although this strategy is designed to engage the apoptosis pathway in otherwise resistant cells, both Bcl-xL and Bcl-2 have also been implicated in the autophagy process.

We next sought to determine if the observed mitochondrial fragmentation led to increased susceptibility to cell death by intrinsic stimuli that engage the mitochondrial pathway.

Pref-1 protein mediates its effects on adipocyte differentiation by directly binding to FN, which activates integrin signaling to engage the MAPK/ERK pathway.