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Since elevated temperatures induce conformational changes in proteins [ 44], an increase in temperature is likely to engage pathways that are relevant to ER stress response.
Similarly, cancer cells have to circumvent replicative telomere shortening and engage pathways to extend telomeres in order to gain unlimited proliferation potential.
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These same patterns are echoed in a zif268 study of spatial learning, as familiar spatial problems preferentially engaged entorhinal cortex to CA1 pathways, while more novel spatial problems engaged pathways from entorhinal cortex to the dentate gyrus and CA3 (Poirier et al., 2008).
Furthermore, due to autonomous processes of absorption of choline metabolites at the small intestine, it makes engaged pathway to understand free choline absorption and supplemented RPC absorption through small intestine and establishes the accurate dietary requirements of choline for dairy ruminants (Cheng et al. 2008).
We define these genes with CDRG larger than 0 as pathway-level differentiated genes, which may potentially represent the whole repertoire of alternations occurring at gene level within the engaged pathway in association with the class contrast or compared phenotypes.
As parity has been suggested to engage multiple pathways, it is likely that there are compensatory pathways that confer protection even when the equilibrium of the cell lineages is disrupted.
Many viruses encode proteins which engage signalling pathways that affect one or more of these mechanisms.
Functional selectivity provides a new avenue to selectively engage particular pathways of the pleiotropic signaling repertoire of a G protein-coupled receptor.
Given that BCL-2 is overexpressed in many tumors, most strategies to engage apoptosis pathways are based in the blockade of anti-apoptotic members of the BCL-2 family.
The ability to engage apoptotic pathways via several routes is likely to be important for the activity of the tumor-suppressor p53.
The potential redundancy among LAZ1 homologs (At1g77220, 55% amino acid identity; At1g23070, 42% identity; Figure S4) may explain the weaker suppression of acd11 by laz1 compared to eds1, as EDS1 may engage other pathways to regulate or execute cell death.
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