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Translation, the second part of the engage component, was the process that made the new information clear and understandable to potential user groups, allowing it to be assimilated.
Introduction of the innovation, the first part of the engage component, referred to giving information about the innovation to the user group.
(Interview #30) The final aspect of the engage component, integration, referred to the embedding of the innovation in the routines and social norms of a user group.
Interestingly both spinophilin and PNUTS also appear to disengage from the surface of PP1 at a similar position (D of spinophilin and N of PNUTS), suggesting that the C-terminal extension of these regulatory subunits evolved to engage component(s) missing from the binary complex.
Similar(56)
All we need is to engage this component.
Interestingly, different drugs may engage distinct components of the apoptotic machinery (Milner et al, 2002).
The potential to engage specific components of the immune system has become central to the rational design of novel antibody therapeutics to exploit Fc-mediated effects more fully.
In particular, antigen presenting cells, such as dentritic cells (DCs), can engage infectious components with their Toll-like receptors (TLRs) (a group of ancient immune recognition molecules) leading to activation of adaptive immune responses and induction of regulatory cells and mediators [ 92, 93].
Instead, as they are generated, the permeable membranes of apoptotic bodies allow the release of limited amounts of DAMPs that would locally engage with components of the innate immune system, thereby providing a mechanism that would contribute to a phased transition between apoptosis and full-blown secondary necrosis.
Boronic acids and their associated derivatives are extensively used for C=C and C=X bond formation.[ 1, 2] Many of these chemistries rely upon passive control of the solution speciation, that is, a catalyst chemoselectively engages one component of a larger mixture with the associated solution equilibria, enabling full conversion into the subsequent intermediate or product.
Similarly, B16 melanoma, previously reported to engage a vascular component in response to single dose radiotherapy[6], is radiosensitized by DC101 (Figure S11), but when implanted in bak−/− mice, which provides radioresistant vasculature [8], similarly exhibited resistance to DC101-induced radiosensitization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com