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However, most of previous microarrayed synthetic polymers do not possess biological ligands (e.g., peptides) to directly engage cell surface receptors.
For cases where mAbs are intended to engage cell surface receptors and prevent receptor-ligand interactions (i.e., antagonists), it may be desirable to reduce or eliminate effector function for example to prevent target cell death or unwanted cytokine secretion.
Bacteria engage cell surface receptors and intracellular signaling molecules to enter the cell.
After 72 hours, cell populations were monitored by fluorescence microscopy and indicate the capacity of both SirT3 and c-myc to avert the p53 –induced cell growth arrest in the EJ-p53 cells, whereas, the control virus containing the GFP cassette alone failed to engage cell proliferation.
What upstream molecular cues instruct neurons to become mature and engage cell survival mechanisms?
Although the precise mechanisms have not yet been elucidated, it is possible that galectin-1 may engage cell surface glycocoproteins involved in cell motility.
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The micro-bubbles engage cells or bacteria and float them into an analytical instrument.
Our previously published in vitro data are in agreement with current in vivo studies which demonstrate that resveratrol can engage cell-intrinsic pathway of apoptosis by regulating the expression of Bcl-2 family of proteins.
Next we sought to determine how calcium triggering depended on the number of engaged cell receptors, by changing ligand density on the particle surface ρL.
By using an optical trap, a microparticle (e.g. cell, bead) can be manipulated non-destructively and directed towards a phagocytic cell, engaging cell surface receptors to trigger the phagocytosis process.
Phenotype MicroArrays use Biolog's redox assays, engaging cell respiration or fermentation as a universal reporter and provide precise quantitation of phenotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com