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These molecules are ligands that engage a complex composed of type I receptor and type II receptors to initiate intracellular signaling.
The two enzymes can be activated independently, but only together do they engage a complex transcription program that results in suppression and apoptosis of T cells.
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Engaging a complex system is more like raising a child.
Through clustering analyses, we noticed that the adhesion-related crosstalk between PML and TNF α engages a complex molecular mechanism.
Once the receptor is engaged, a complex is formed between MyD88, TRAF6, IRAK4, and IRAK1 that allows for activation of IRF [ 22, 23].
Cytochrome c engages a complex containing Apaf-1 and caspase-9 that in the presence of ATP forms a large molecular weight complex of active caspase-9 known as the apoptosome (Cain et al. 2000).
Specificity may lie rather in the recruitment of particular combinations of subunits, such that chemotropic BMPs engage a receptor complex whose composition is distinct from complexes mediating inductive responses evoked by a majority of BMPs (Figure 8).
Together, our findings therefore fit best with a scheme in which chemotropic BMPs, typified by BMP7, engage a receptor complex in which the type II component is a heterodimer of ActRIIA and BMPRII (Figure 8A).
There is now abundant evidence that, under physiological conditions, proNTs exit the cell and engage a distinct receptor complex consisting of p75NTR and sortilin that can initiate cell death, especially in cases of neuronal trauma or stress (Jansen et al., 2007; Nykjaer & Willnow, 2012).
It will continue to engage in a complex struggle with radical Islam.
Cars cannot park on the street in the summer, and those who share driveways have to engage in a complex dance with the neighbors.
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