This finding contrasts with extreme CUB, which enforces structure and regularity on DNA sequence.
For example, the upper-layer clusters may represent two-digit human leukocyte antigen (HLA) allele classes (such as HLA-A02 and HLA-A03), which enforce structure on the lower-layer clusters that represent four-digit HLA alleles (such as HLA-A0202, HLA-A0203, HLA-A0301, HLA-A03030303).
"Rules of taste enforce structures of power," Sontag wrote.
"I'm not enforcing a structure for social change.
The paper defends the choice of the control configuration and argues that when using MIMO design procedures, enforcing some structure upon the transfer function matrix makes the controller implementation and fine-tuning easier.
FA models are often been advocated for their parsimony: for problems of relatively high dimensions, reduced sampling variances due to a greatly reduced number of parameters can easily outweigh small biases due to enforcing such structure but, as emphasized above, we need to ensure that the set of factors fitted includes all important factors.
Brendan is important because he knows how to say "we need 14 wees and two poos, can we use your pissoir?" in 20 European languages, and crucially he enforces the structure.
Interestingly, the reported resistance of HIV-1 to RISC-mediated miRNA regulation [ 116] could theoretically be due in part to effects of small RNA, which may enforce transcript structure and transport [ 123, 124].
It has been suggested that these types of molecules play a strictly mechanical role that requires a surfactant activity, possibly by enforcing an amphipathic structure via the posttranslational modifications.
More recently, direct estimation enforcing a FA structure has been proposed and suitable algorithms for both restricted maximum likelihood (REML) [ 5, 6, 44, 45] and Bayesian estimation [ 46] have been described, and mixed model software packages available, such as ASReml [ 47] or WOMBAT [ 48], readily accommodate such analyses.
