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In this view, although Prp16 is the key player in mediating fidelity control of the first reaction, Cwc25 plays an important role in enforcing specificity of branchpoint recognition [ 70, 195].
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Historically, many approaches to nonmonotonic reasoning, including default logic, circumscription, and autoepistemic logic, do not provide an account of specificity, and so fail to enforce specificity among default sentences.
Here, we suggest that protein phosphatases could be part of the regulatory mechanisms to enforce specificity in signal transduction.
Here, we have analyzed the interactions of an aminoacyl-tRNA synthetase for which strong evolutionary pressure has enforced high specificity for substrate binding and catalysis.
We propose that the distinct modes of interaction with PDEs provide an additional layer of complexity to enforce the specificity of β1- and β2-adrenoceptor signaling.
During the synthesis of the second stranded cDNA, deoxythymidine triphosphate (dTTP) was substituted with deoxyuridine triphosphate (dUTP), which helped enforce strand specificity (Wang et al. 2011).
We propose that the distinct modes of interaction with PDEs result in divergent cAMP signals in the vicinity of the two receptors, thus, providing an additional layer of complexity to enforce the specificity of β1- and β2-adrenoceptor signaling.
This substitution may therefore be of relevance in explaining the differential activity of Bacteroides and eukaryotic enzymes toward lower inositol phosphate substrates by enforcing more positional specificity on the mammalian enzyme.
Although the uniform risk assessment approach (using the "infected premises" principle) adopted in "Incident I" can be implemented rapidly and easily enforced, it lacks the specificity required when advising anxious workers on the need for antiviral prophylaxis.
But these need enforcing.
The problem is enforcing it.
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CEO of Professional Science Editing for Scientists @ prosciediting.com