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However, enforcing expression of OBF1 in this population induces an accumulation of EPLMs with a strong B cell commitment deficiency (Fig. 3).
Therefore we hypothesized that the combination of silencing DNA polymerases and enforcing expression of recombinant active Caspase 3 should have potent antitumor effect which may inhibit cell proliferation while trigger apoptosis.
To evaluate the ability of p21 to stabilize the cyclin D cdk4 complex during PDGF-induced tumor development, we asked if enforcing expression of functional cyclin D1 cdk4 complexes would be sufficient to overcome the effect of p21 deficiency on tumor growth.
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However, dysplastic changes were seen in miR-142 expressing cells while enforced expression of miR-150 only resulted in hyperproliferative changes.
Furthermore, the enforced expression of miR-142-3p miR-142-3p miR-142-3p miRNa, cauniquelyignificant dexpressedn primiRNAe erythrocausesrogenitor cells and Hsignificant
When this enforced expression of Hb was removed, neuroblasts expressed Kr and continued on to the later competence states [25].
The enforced expression of miR-17-92 miR-17-92 miR-17-92ssion from inducing preventsative arrest, senescence, and apoptosis and abrogates sustained tuMYC regresuppression
Par-4 is essential for apoptosis and enforced expression of Par-4 sensitizes cells to p53-independent apoptosis.
However, enforced expression of NF1-LRD reduced cell invasion by approximately 70% (Fig. 4b(i) and (ii)) in comparison to the vector control.
In these models, enforced expression of the transcription factors C/EBPα and C/EBPβ promoted trans-differentiation of B cells into macrophages.
As expected, enforced expression of c-ETS1 severely compromised DNA replication whereas its down-regulation enhanced DNA replication as evident from increased BrdU incorporation.
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