A study now explores how clonal expansion of epidermal stem cells with specific oncogenic mutations might be restricted by their elimination through enforced differentiation.
BRD guarantees each class losses that, when feasible, are no worse than a specified bound, while enforcing differentiation only when required to meet those bounds.
Federica Mogherini, the EU's foreign policy chief, is not thought to be an ardent advocate at present of further practical steps to enforce differentiation between Israel and Israeli settlements, while one previously strongly pro-Palestinian EU member, Greece, is said to have shifted its position, seeking better economic and diplomatic relations with Israel.
In an attempt to isolate primitive human thyroid epithelial cells, we tried several commercially available media containing growth factors but not serum which is generally thought to enforce differentiation program.
These cells were also cultured in the presence of serum, a potent source of signalling activity, that we propose will compensate for FGF signalling and enforce differentiation of the cells to the ectoderm.
Alternatively, depending on the latter strategies effectiveness to enforce differentiation, RARRES3 activation could offer a useful pretreatment to improve the effect of conventional therapies.
Reviewer #3: The claim that adult human pancreatic duct cells have a latent capacity for endocrine differentiation is correct, but only in this context of extremely strong transcription-factor-based enforced differentiation.
However, it has been also postulated that GATA3 defines a distinct class of cancer genes that are differentiation factors rather than conventional tumor suppressor genes, which affect the malignant phenotype by enforcing differentiation [ 5- 7].
Sykes, S. M. et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
The TaLE framework installed at the AP actually enforces the differentiation together with the feedback control of TCP (or TCP-like) protocol.
