Sentence examples for enforce the checkpoints from inspiring English sources
This loss of robust checkpoint control and subsequent escape from G2 arrest is likely due at least in part to destabilization of mutant p53, combined with a cellular state in which there is insufficient p21 activity (both intrinsically and via the HSP90 inhibitor-mediated loss of mutant p53) to enforce the checkpoints.
Dimitrova, N. et al. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint.
Genes that play important roles in the G1/S transition and initiation of DNA replication, including CCNE, CDK2, CDC6, CDC45, CDC7, RFC subunits, and MCM family members, were down-regulated at 6 and 24 hr post-IR as an expected consequence of the p53-dependent induction of CDKN1A (p21Waf1) to enforce the G1 checkpoint response.
In this context, ATM signaling delays the entry into mitosis by causing inactivation of CDC25C and thereby enforces the G2 checkpoint.
This is because eukaryotic spindles use essentially the same microtubule-kinetochore interface structure repeated for every chromosome, and the collective decisions such as when to enter anaphase are carried out by checkpoint machineries that enforce the rule that all of the kinetochores must be attached before the next step can proceed [ 18].
In this case it was a shame that the exclusion zone was not better secured; there were no checkpoints or barriers to enforce the authorities' warning.
Checkpoints have been set up to prevent shipments of the stimulant drug from entering the southern port city, while patrols roamed markets to enforce the ban, witnesses said on Monday.
Gordon The N.Y.P.D. must enforce the law.
"To enforce the law means everything".
The model should not enforce the clock.
